Power Blue (Methylene Blue)

Overview

Power Blue or Methylene Blue (MB) is a water-soluble, synthetic phenothiazine compound with a long history of use in medicine, chemistry, and biology. Originally developed as a textile dye in the 19th century, it was later discovered to have pharmacological properties, including redox cycling, mitochondrial enhancement, neuroprotection, and antimicrobial activity.

Chemical Information

• Chemical Formula: C₁₆H₁₈ClN₃S
• Molecular Weight: 319.85 g/mol
• CAS Number: 61-73-4
• Solubility: Water-Soluble

Storage & Stability

• Storage Temperature: Room temperature (15-25°C)
• Shelf Life: Stable for up to three years when stored in a cool, dark place
• Avoid Direct Light: MB is photosensitive and should be kept in an amber or opaque container to maintain potency

Key Features

• High Purity (USP-Grade) – Ensuring top-tier research applications
• 1% Aqueous Solution – Precisely formulated for research use
• Redox Agent – Plays a key role in cellular respiration and ATP production
• Neuroprotective Properties – Supports mitochondrial function and cognitive performance
• Antimicrobial and Antiviral Effects – Used for its antibacterial, antifungal, and antiviral properties
• Methemoglobinemia Treatment – Recognized by the FDA for reversing methemoglobinemia
• Enhances Energy Metabolism – Supports cellular energy production via the mitochondrial electron transport chain

Mechanism of Action

Methylene Blue functions as an electron donor and acceptor, meaning it facilitates electron transport in mitochondrial respiration. It improves ATP production by bypassing Complex I & III of the electron transport chain, reducing oxidative stress and boosting energy metabolism.
Additionally, MB is a monoamine oxidase (MAO) inhibitor, which means it can influence neurotransmitter levels, particularly dopamine and serotonin, making it a potential nootropic for cognitive enhancement.

Potential Benefits

• Mitochondrial Support & Energy Production – Enhances ATP synthesis by improving mitochondrial efficiency, making it useful for fatigue-related conditions.
• Cognitive Function & Neuroprotection – MB has been studied for its role in Alzheimer’s, Parkinson’s, and other neurodegenerative conditions due to its ability to improve memory retention, increase blood flow to the brain, and reduce oxidative damage.
• Anti-Aging & Longevity – As a potent antioxidant, MB neutralizes reactive oxygen species (ROS), reducing cellular damage and supporting longevity research.
• Antimicrobial Properties – Exhibits antibacterial, antifungal, and antiviral effects. Historically used to treat urinary tract infections and malaria.
• Mood & Mental Clarity – As an MAO inhibitor, MB has been investigated for its ability to modulate serotonin and dopamine levels, potentially improving mood, reducing depression, and enhancing focus.
• Anti-Inflammatory Effects – MB is shown to reduce inflammation in multiple pathways, supporting overall health and cellular function.

Research Applications

• Neurodegenerative Disease Models – Investigated for potential applications in Alzheimer’s, Parkinson’s, and traumatic brain injury.
• Cellular Respiration Studies – Used in research to analyze mitochondrial efficiency and redox balance.
• Antibacterial & Antiviral Research – Studied as an alternative to conventional antimicrobial agents.
• Photodynamic Therapy – MB is used in research for its light-activated properties to treat infections and cancer cells.

Recommended Dosage & Administration

Methylene Blue is widely researched, and its dosing depends on intended use:

• Low-Dose (Cognitive & Mitochondrial Support): 0.5 mg – 4 mg per kg body weight
• Medium-Dose (Methemoglobinemia Treatment): 1 – 2 mg/kg intravenously
• High-Dose (Antimicrobial Use & Research Applications): 10 mg – 50 mg per kg body weight

Methylene Blue should never be combined with SSRIs, SNRIs, or MAOIs, as it can cause serotonin syndrome, a potentially dangerous condition. Always research interactions before use.

Safety & Side Effects

Methylene Blue is well tolerated at low doses but can cause adverse effects at higher doses.

Common Side Effects:

• Mild nausea or stomach discomfort
• Temporary blue or green urine discoloration (normal)
• Headaches (typically transient)

Potential Risks at Higher Doses:

• Serotonin Syndrome: Due to MAO inhibition, MB should never be combined with SSRIs, SNRIs, or other serotonergic drugs.
• Oxidative Stress at High Doses: While MB is an antioxidant at low doses, excessive amounts may lead to pro-oxidant effects.
• Gastrointestinal Distress: Some users experience nausea, diarrhea, or vomiting at higher doses.

Frequently Asked Questions

What is Methylene Blue used for in research?

It is commonly used for studying mitochondrial function, cognitive enhancement, antimicrobial effects, and cellular respiration.

Can Methylene Blue improve cognitive function?

Yes, MB has been shown to enhance memory, attention, and cognitive processing speed in both animal and human studies.

Is Methylene Blue safe?

At low doses, MB is generally safe, but it should not be mixed with serotonergic medications.

Does Methylene Blue stain teeth or skin?

It can temporarily stain tissues, but it is water-soluble and can be rinsed off easily.

Can Methylene Blue be used for photodynamic therapy?

Yes, MB is used in research involving light-activated antimicrobial and anticancer applications.

For Research Purposes Only

Methylene Blue is sold strictly for laboratory and research use. It is not intended for human consumption or medical treatment.

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